Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis
نویسندگان
چکیده
منابع مشابه
RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.
In intestinal epithelial cells, inactivation of APC, a key regulator of the Wnt pathway, activates beta-catenin to initiate tumorigenesis. However, other alterations may be involved in intestinal tumorigenesis. Here we found that RUNX3, a gastric tumor suppressor, forms a ternary complex with beta-catenin/TCF4 and attenuates Wnt signaling activity. A significant fraction of human sporadic color...
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catenin is a critical mediator of the Wnt canonical pathway for multiple cellular responses. Using transgenic mice, loss or activation of β-catenin has been studied in multiple tissues to elucidate its role in vivo. In this editorial, we focus on recent findings examining the involvement of β-catenin in cancer initiation and progression of epithelial tissues in thymus and prostate. β-catenin in...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2020
ISSN: 0950-9232,1476-5594
DOI: 10.1038/s41388-020-01538-y